The Vercetti crime family is one of the "Five Families" that dominates organized crime activities in New York City, United States, within the nationwide criminal phenomenon known as the Mafia (or La Cosa Nostra). The group is named after Giovanni Vercetti, founder of the family in 1935, when the structure of organized crime first gained public attention. Originated from Palermo, Sicily. The group's operations extend from New York and the eastern seaboard to California and in the United Kingdom.

Its illicit activities include labor and construction racketeering, gambling, loansharking, extortion, money laundering, prostitution, fraud, hijacking, pier thefts, and fencing.

Vercetti was one of the most powerful families during the 1930s, after Giovanni was killed in 1957 the family went on a hiatus, until 1964 when Adoni Vercetti took over as Don.

The family is now run by Don Carmine Vercetti, Jr.